Direct activation of telomerase by GH via phosphatidylinositol 3′-kinase
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چکیده
منابع مشابه
Muscle Cell Migration via Activation of Phosphatidylinositol 3-Kinase
The steroid hormone 1 ,25-dihydroxyvitamin D3 [1 ,25-(OH)2D3] promotes vascular smooth muscle cell (VSMC) growth and calcification, but the precise mechanism by which 1 ,25-(OH)2D3 regulates VSMC migration is unknown. In rat aortic SMCs, we found that 1 ,25-(OH)2D3 (0.1 to 100 nmol/L) induced a dose-dependent increase in VSMC migration. This response required the activation of phosphatidylinosi...
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OBJECTIVE In the functional screening of a human heart cDNA library to identify a novel antiangiogenic factor, the prime candidate gene was "four-and-a-half LIM only protein-2" (FHL-2). The goal of this study is to clear the mechanism of antiangiogenic signaling of FHL-2 in endothelial cells (ECs). METHODS AND RESULTS Overexpressed FHL-2 strongly inhibited vascular endothelial growth factor (...
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Objective(s): Drug-induced atrial fibrillation (AF) is considered an adverse effect of chemotherapeutic drugs. AF is a crucial risk factor for stroke, heart failure, myocardial infarction, and mortality. Pulmonary veins (PVs) are considered triggers inducing AF, and the sinoatrial node (SAN) may modulate PV activity and participate in AF genesis. AF was associated with...
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Phosphatidylinositol (PI) 3-kinases have been implicated in several aspects of intracellular membrane trafficking, although a detailed mechanism is yet to be established. In this study we demonstrated that wortmannin, a specific inhibitor of PI 3-kinases, inhibited constitutive endocytosis of horseradish peroxidase and transferrin in BHK-21 and TRVb-1 cells. The IC50 was approximately 40 ng/ml ...
متن کامل1 ,25-Dihydroxyvitamin D3 Induces Vascular Smooth Muscle Cell Migration via Activation of Phosphatidylinositol 3-Kinase
The steroid hormone 1 ,25-dihydroxyvitamin D3 [1 ,25-(OH)2D3] promotes vascular smooth muscle cell (VSMC) growth and calcification, but the precise mechanism by which 1 ,25-(OH)2D3 regulates VSMC migration is unknown. In rat aortic SMCs, we found that 1 ,25-(OH)2D3 (0.1 to 100 nmol/L) induced a dose-dependent increase in VSMC migration. This response required the activation of phosphatidylinosi...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2005
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe.1.05766